Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Abstract excerpt

BACKGROUND: One recent study reports cancer driver mutations in deep endometriosis, but its biological/clinical significance remains unclear. Since the natural history of endometriosis is essentially gradual progression toward fibrosis, it is thus hypothesized that the six driver genes reported to be mutated in endometriosis (the RP set) may play important roles in fibrogenesis but not necessarily malignant...

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