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Structural and Nonstructural Genes Contribute to the Genetic Diversity of RNA Viruses

29 Oct 2018

Abstract excerpt

With the advent of advanced sequencing technology, studies of RNA viruses have shown that genetic diversity can contribute to both attenuation and virulence and the paradigm is that this is controlled by the error-prone RNA-dependent RNA polymerase (RdRp). Since wild-type yellow fever virus (YFV) strain Asibi has genetic diversity typical of a wild-type RNA virus, while 17D virus vaccine has limited diversity, it...

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PMID: 30377281
DOI: 10.1128/mbio.01871-18

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