Article
Comparison of the live attenuated yellow fever vaccine 17D-204 strain to its virulent parental strain Asibi by deep sequencing.
The Journal of infectious diseases - 1 Feb 2014
Beck Andrew, Tesh Robert B, Wood Thomas G, Widen Steven G, Ryman Kate D, Barrett Alan D T
Abstract excerpt
BACKGROUND: The first comparison of a live RNA viral vaccine strain to its wild-type parental strain by deep sequencing is presented using as a model the yellow fever virus (YFV) live vaccine strain 17D-204 and its wild-type parental strain, Asibi. METHODS: The YFV 17D-204 vaccine genome was compared to that of the parental strain Asibi by massively parallel methods. Variability was compared on multiple scales of...
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