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Lynch Syndrome and Somatic Mismatch Repair Variants in Pancreas Cancer

5 Sept 2024

Abstract excerpt

Importance: Microsatellite (MS) instability (MSI-H) occurs frequently in Lynch syndrome (LS)-associated tumors and is associated with response to immune checkpoint blockade (ICB) therapy. MSI-H is conferred by germline or somatic variants in mismatch repair genes. The contribution of somatic oncogenesis to MSI-H in pancreatic cancer (PC) is unknown. Objective: To evaluate an LS-related PC cohort to define...

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PMID: 39235819
DOI: 10.1001/jamaoncol.2024.3651

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