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Article

Phenotype-specific white matter microstructural alterations and their clinical correlates in Wilson disease.

Scientific reports - 6 Aug 2026

Hausmann Ann Carolin, Querbach Silja K, Rubbert Christian, Schnitzler Alfons, Caspers Julian, Hartmann Christian Johannes

Abstract excerpt

Wilson disease (WD) is a genetic disorder of copper metabolism that leads to progressive brain damage, yet the microstructural mechanisms underlying white matter alterations remain insufficiently understood. Diffusion tensor imaging provides limited biological specificity and is sensitive to free water contamination. Therefore, we applied neurite orientation dispersion and density imaging to characterize white...

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PMID: 42562855
DOI: 10.1038/s41598-026-65470-z
PMCID: PMC13447857

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