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Article

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.

The Journal of clinical investigation - 1 Sept 2017

Chang Sook Kyung, Kohlgruber Ayano C, Mizoguchi Fumitaka, Michelet Xavier, Wolf Benjamin J, Wei Kevin, Lee Pui Y, Lynch Lydia, Duquette Danielle, Ceperuelo-Mallafré Victòria, Banks Alexander S, Brenner Michael B

Abstract excerpt

M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while M1 macrophages, TNF, and other inflammatory cytokines drive inflammation and insulin resistance in obesity. Stromal cells regulate leukocyte responses in lymph nodes, but the role of stromal cells in adipose tissue inflammation is unknown. PDGFRα+...

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Topics

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Experimental

Share to Glucose Intolerance

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Share to Interleukin-33

Share to Mice, Obese

Source

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Identifiers

PMID: 28758901
DOI: 10.1172/JCI86881
PMCID: PMC5669565

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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