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Article

An intronic genetic variation of MGMT affects enhancer activity and is associated with glioma susceptibility

1 Sept 2018

Abstract excerpt

Purpose: O 6 -methylguanine-DNA methyltransferase (MGMT) plays a crucial role in repairing damaged DNA caused by alkylating agents. A number of cancer susceptibility loci have been recognized as enhancer variants. This study aimed to explore the significance of enhancer variants of MGMT in glioma susceptibility. Patients and methods: A retrospective case-control study consisting of 150 glioma patients and 327...

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Share to Chromatin Remodeling and Cancer
Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30310321
DOI: 10.2147/cmar.s176622

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