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Article

MGMT gene variants, temozolomide myelotoxicity and glioma risk. A concise literature survey including an illustrative case.

Journal of chemotherapy (Florence, Italy) - 1 Aug 2017

Altinoz Meric A, Elmaci Ilhan, Bolukbasi Fatih Han, Ekmekci Cumhur Gokhan, Yenmis Guven, Sari Ramazan, Sav Aydin

Abstract excerpt

Temozolomide may cause thrombocytopenia or neutropenia in 3-4% of glioblastoma patients, respectively. However, pancytopenia is rarely reported. MGMT (O6-methylguanine-DNA-methyltransferase) enzyme repairs temozolomide-induced DNA mutations and associates both with antitumour efficacy and myelosuppression. Many studies on the effects of MGMT gene-methylation on temozolomide's effects exist, but much fewer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28436299
DOI: 10.1080/1120009X.2017.1312752

Genes

MGMT

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