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Article

MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma

9 Mar 2005

Abstract excerpt

BACKGROUND: Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents. METHODS: We tested the relationship between MGMT silencing in the tumor and the survival of patients who were enrolled in a randomized trial comparing...

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Identifiers

PMID: 15758010
DOI: 10.1056/nejmoa043331

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