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Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2

5 Oct 2018

Abstract excerpt

All breast cancers are assessed for levels of human epidermal growth factor receptor 2 (HER2). Fluorescence in situ hybridization (FISH) and immunohistochemistry are currently used to determine if a patient is eligible for anti-HER2 therapy. Limitations of both tests include variability and relatively long processing times. Additionally, neither test determines whether HER2 contains the extracellular domain....

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PMID: 30310083
DOI: 10.1038/s41598-018-33225-0

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