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Liquid-phase electron microscopy of molecular drug response in breast cancer cells reveals irresponsive cell subpopulations related to lack of HER2 homodimers

9 Aug 2017

Abstract excerpt

The development of drug resistance in cancer poses a major clinical problem. An example is human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer often treated with anti-HER2 antibody therapies, such as trastuzumab. Since drug resistance is rooted mainly in tumor cell heterogeneity, we examined the drug effect in different subpopulations of SKBR3 breast cancer cells, and compared the results...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28794264
DOI: 10.1091/mbc.e17-06-0381

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