Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developing a Paired Whole Genome Sequencing Service for Children With Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain)) - 1 Feb 2025

Sarkies L, Thomas P, Edeko E A, Leiter S, Trotman J, Armstrong R, Vedi A

Abstract excerpt

BACKGROUND: The uniqueness of paired (tumor and germline) whole genome sequencing (PWGS) in cancer diagnosis and management lies in not just its ability to uncover oncogenic drivers and potential treatment targets but also on the identification of underlying cancer predisposition syndromes, which has significant implications for the patient and their family. AIMS: This is a descriptive article highlighting the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NHS gene

Share to Genetic Predisposition to Disease

Share to Genetic Testing

Share to Neoplasms

Share to Whole Genome Sequencing

Source

Identifiers

PMID: 39214827
DOI: 10.1016/j.clon.2024.07.009

Genes

NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developing a Paired Whole Genome Sequencing Service for Children With Cancer.PMID 39214827Read ↗

Germline sequencing in children with cancer in Quebec: an integrated investigative approachSemantic proximity Read ↗

Protocol for a comprehensive prospective cohort study of trio-based whole-genome sequencing for underlying cancer predisposition in paediatric and adolescent patients newly diagnosed with cancer: the PREDICT study.Semantic proximity Read ↗

Childhood cancer predisposition study: a prospective registry and biorepository protocol.Semantic proximity Read ↗

Integrated Germline and Somatic Molecular Profiling to Detect Cancer Predisposition Has a High Clinical Impact in Poor-Prognosis Pediatric Cancer.Semantic proximity Read ↗

Genomic Newborn Screening for Pediatric Cancer Predisposition Syndromes: A Holistic ApproachSemantic proximity Read ↗

Pediatric Cancer Genetics and Genomics.Semantic proximity Read ↗

Family-based germline sequencing in children with cancerSemantic proximity Read ↗

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.Semantic proximity Read ↗

[Germ line mutations causing paediatric cancer predisposition syndromes are common in children and adolescents with cancer].Semantic proximity Read ↗

Integrated germline and somatic molecular profiling to detect cancer predisposition has a high clinical impact in poor-prognosis paediatric cancerSemantic proximity Read ↗

Collaboration to Promote Research and Improve Clinical Care in the Evolving Field of Childhood Cancer Predisposition.Semantic proximity Read ↗

The genetic era of childhood cancer: Identification of high-risk patients and germline sequencing approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.