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Article

Genetic predisposition in children with cancer - affected families' acceptance of Trio-WES.

European journal of pediatrics - 1 Jan 2018

Brozou Triantafyllia, Taeubner Julia, Velleuer Eunike, Dugas Martin, Wieczorek Dagmar, Borkhardt Arndt, Kuhlen Michaela

Abstract excerpt

A considerable percentage of childhood cancers are due to cancer predisposition syndromes (CPS). The ratio of CPSs caused by inherited versus de novo germline mutations and the risk of recurrence in other children are unknown. We initiated a prospective study performing whole-exome sequencing (WES) of parent-child trios in children newly diagnosed with cancer. We initially aimed to determine the interest in and...

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Identifiers

PMID: 28929227
DOI: 10.1007/s00431-017-2997-6
PMCID: PMC5748429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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