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Article

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2017

Kim Joo Young, Brosnan-Cashman Jacqueline A, An Soyeon, Kim Sung Joo, Song Ki-Byung, Kim Min-Sun, Kim Mi-Ju, Hwang Dae Wook, Meeker Alan K, Yu Eunsil, Kim Song Cheol, Hruban Ralph H, Heaphy Christopher M, Hong Seung-Mo

Abstract excerpt

Purpose: Alternative lengthening of telomeres (ALT), a telomerase-independent telomere maintenance mechanism, is strongly associated with ATRX and DAXX alterations and occurs frequently in pancreatic neuroendocrine tumors (PanNET).Experimental Design: In a Korean cohort of 269 surgically resected primary PanNETs and 19 sporadic microadenomas, ALT status and nuclear ATRX and DAXX protein expression were assessed...

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Identifiers

PMID: 27663587
DOI: 10.1158/1078-0432.CCR-16-1147
PMCID: PMC5354973

Genes

ATRX
DAXX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival.PMID 27663587Read ↗

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