Article

MAML3-fusions modulate Vascular and Immune Tumor Microenvironment and Confer High Metastatic Risk in Pheochromocytoma and Paraganglioma

2023-11-30

Abstract excerpt

<title>Abstract</title> <p>Background Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that encompass a genetically heterogeneous disease. Approximately 20-25% of diagnosed cases develop metastases, for which there is an absence of predictive markers and therapeutic stratification strategies. MAML3-fusions in PPGL are associated with increased metastatic risk; however, neither the proce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85430ff7-91d6-5f24-849f-19dbde3f54b8
DOI: 10.21203/rs.3.rs-3672711/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MAML3-fusions modulate Vascular and Immune Tumor Microenvironment and Confer High Metastatic Risk in Pheochromocytoma and ParagangliomaDOI 10.21203/rs.3.rs-3672711/v1Read

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.Semantic proximity Read

Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression.Semantic proximity Read

Genomic and immune landscape Of metastatic pheochromocytoma and paragangliomaSemantic proximity Read

The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic DiseaseSemantic proximity Read

Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironmentSemantic proximity Read

PPGLomics: An Interactive Platform for Pheochromocytoma and Paraganglioma TranscriptomicsSemantic proximity Read

Genetics of pheochromocytoma and paraganglioma.Semantic proximity Read

Transcriptional Subtypes on Immune Microenvironment and Predicting Postoperative Recurrence and Metastasis in Pheochromocytoma and ParagangliomaSemantic proximity Read

Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision MedicineSemantic proximity Read

Pheochromocytoma–Paraganglioma Syndrome: A Multiform Disease with Different Genotype and Phenotype FeaturesSemantic proximity Read

Personalized Management of Pheochromocytoma and Paraganglioma.Semantic proximity Read

ScRNA-seq of Diverse Pheochromocytoma Patients Reveals Distinct Microenvironment Characteristics and Supports an Informative Molecular Classification SystemSemantic proximity Read