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Article

Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration

1 Sept 2018

Abstract excerpt

Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to blood from young mice by parabiosis counteracts this regenerative capacity. The secreted factor,...

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Identifiers

PMID: 30257200
DOI: 10.1016/j.celrep.2018.08.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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