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Granulocyte colony stimulating factor promotes scarless tissue regeneration

21 Sept 2024

Abstract excerpt

Mammals typically heal with fibrotic scars, and treatments to regenerate human skin and hair without a scar remain elusive. We discovered that mice lacking C-X-C motif chemokine receptor 2 (CXCR2 knockout [KO]) displayed robust and complete tissue regeneration across three different injury models: skin, hair follicle, and cartilage. Remarkably, wild-type mice receiving plasma from CXCR2 KO mice through parabiosis...

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PMID: 39306847
DOI: 10.1016/j.celrep.2024.114742

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