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Article

Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells

21 Nov 2014

Abstract excerpt

Advanced age is associated with an increased risk of vascular morbidity, attributable in part to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have previously been shown to play an important role in neovascularization and deficiencies in these cells have been described in aged patients. Here we utilize single cell transcriptional analysis to determine the effect of aging on MSC...

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PMID: 25413454
DOI: 10.1038/srep07144

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