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Article

The burden of rare damaging variants in hereditary atypical parkinsonism genes is increased in patients with Parkinson's disease.

Neurobiology of aging - 1 Apr 2021

Kim Yun Joong, Lee Jinwoo, Kim Nan Young, Hong SangKyoon, Cho Yoon Shin, Yoon Jeehee

Abstract excerpt

Increased burdens of rare coding variants in genes related to lysosomal storage disease or mitochondrial pathways were reported to be associated with idiopathic Parkinson's disease. Under a hypothesis that the burden of damaging rare coding variants is increased in causative genes for hereditary parkinsonism, we analyzed the burdens of rare coding variants with a case-control design. Two cohorts of whole-exome...

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Identifiers

PMID: 33423827
DOI: 10.1016/j.neurobiolaging.2020.11.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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