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Article

TET2 deficiency leads to stem cell factor–dependent clonal expansion of dysfunctional erythroid progenitors

25 Sept 2018

Abstract excerpt

Myelodysplastic syndromes (MDSs) are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Anemia is the defining cytopenia of MDS patients, yet the molecular mechanisms for dyserythropoiesis in MDSs remain to be fully defined. Recent studies have revealed that heterozygous loss-of-function mutation of DNA dioxygenase TET2 is 1 of the most common mutations in MDSs and that TET2...

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PMID: 30254129
DOI: 10.1182/blood-2018-05-853291

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