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Article

Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo

17 Aug 2018

Abstract excerpt

Circular RNAs (circRNAs) are long-lived, covalently closed RNAs that are abundantly expressed and evolutionarily conserved across eukaryotes. Possible functions ranging from microRNA (miRNA) and RNA binding protein sponges to regulators of transcription and translation have been proposed. Here we describe the design and characterization of recombinant adeno-associated viral (AAV) vectors packaging transgene...

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PMID: 30245471
DOI: 10.1016/j.omtn.2018.08.008

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