Article
MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1.
Molecular cancer - 18 Aug 2011
Dong Peixin, Kaneuchi Masanori, Watari Hidemichi, Hamada Junichi, Sudo Satoko, Ju Jingfang, Sakuragi Noriaki
Abstract excerpt
BACKGROUND: Epithelial-mesenchymal transition (EMT) is the key process driving cancer metastasis. Oncogene/self renewal factor BMI-1 has been shown to induce EMT in cancer cells. Recent studies have implied that noncoding microRNAs (miRNAs) act as crucial modulators for EMT. The aims of this study was to determine the roles of BMI-1 in inducing EMT of endometrial cancer (EC) cells and the possible role of miRNA...
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