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Article

SNAI2 Attenuated the Stem-like Phenotype by Reducing the Expansion of EPCAMhigh Cells in Cervical Cancer Cells.

International journal of molecular sciences - 5 Jan 2023

Liu Xian, Zhang Ni, Chen Qian, Feng Qian, Zhang Yanru, Wang Zhiqiang, Yue Xiong, Li Hongbao, Cui Nan

Abstract excerpt

SNAI2 (Snai2) is a zinc-finger transcriptional repressor that belongs to the Snail family. The accumulated evidence suggests that SNAI2 exhibits biphasic effects on regulating a stem-like phenotype in various types of cells, both normal and malignant. In this study, by exogenously expressing SNAI2 in SiHa cells, SNAI2 exhibited the capacity to inhibit a stem-like phenotype in cervical cancer cells. The...

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Identifiers

PMID: 36674577
DOI: 10.3390/ijms24021062
PMCID: PMC9864029

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