Article
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Cell metabolism - 3 Jul 2012
Taneera Jalal, Lang Stefan, Sharma Amitabh, Fadista Joao, Zhou Yuedan, Ahlqvist Emma, Jonsson Anna, Lyssenko Valeriya, Vikman Petter, Hansson Ola, Parikh Hemang, Korsgren Olle, Soni Arvind, Krus Ulrika, Zhang Enming, Jing Xing-Jun, Esguerra Jonathan L S, Wollheim Claes B, Salehi Albert, Rosengren Anders, Renström Erik, Groop Leif
Abstract excerpt
Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed global gene expression in human islets from 63 donors. Using 48 genes located near T2D risk variants, we identified gene coexpression and protein-protein interaction networks that were strongly associated with islet insulin secretion...
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