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Allele-specific Methylation of Imprinted Genes in Fetal Cord Blood is Influenced By Cis-Acting Genetic Variants and Parental Factors

21 Sept 2018

Abstract excerpt

AIM: To examine the effects of genetic variation, parental age and BMI on parental allele-specific methylation of imprinted genes in fetal cord blood samples. METHODOLOGY: We have developed SNP genotyping and deep bisulphite sequencing assays for six imprinted genes to determine parental allele-specific methylation patterns in diploid somatic tissues. RESULTS: Multivariate linear regression analyses revealed a...

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Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
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PMID: 30238782
DOI: 10.2217/epi-2018-0059

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