Article
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Nature communications - 11 Jun 2019
Czamara Darina, Eraslan Gökçen, Page Christian M, Lahti Jari, Lahti-Pulkkinen Marius, Hämäläinen Esa, Kajantie Eero, Laivuori Hannele, Villa Pia M, Reynolds Rebecca M, Nystad Wenche, Håberg Siri E, London Stephanie J, O'Donnell Kieran J, Garg Elika, Meaney Michael J, Entringer Sonja, Wadhwa Pathik D, Buss Claudia, Jones Meaghan J, Lin David T S, MacIsaac Julie L, Kobor Michael S, Koen Nastassja, Zar Heather J, Koenen Karestan C, Dalvie Shareefa, Stein Dan J, Kondofersky Ivan, Müller Nikola S, Theis Fabian J, Räikkönen Katri, Binder Elisabeth B
Abstract excerpt
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in...
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