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Article

The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease

17 Sept 2018

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. PGC-1α, encoded by PPARGC1A, is a transcriptional co-activator that has been implicated in the pathogenesis of neurodegenerative disorders. We recently discovered multiple new PPARGC1A transcripts that initiate from a novel promoter located far upstream of the reference gene promoter, are CNS-specific and are more abundant...

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PMID: 30236862
DOI: 10.1016/j.nbd.2018.09.016

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