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Article

Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

20 Sept 2018

Abstract excerpt

BACKGROUND: Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to offspring are poorly understood. RESULTS: Here we provide evidence that Polycomb Repressive Complex 2 (PRC2) regulates...

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PMID: 30236109
DOI: 10.1186/s12915-018-0569-5

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