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Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

11 Sept 2018

Abstract excerpt

Nearly all patients with small cell lung cancer (SCLC) eventually relapse with chemoresistant disease. The molecular mechanisms driving chemoresistance in SCLC remain un-characterized. Here, we describe whole-exome sequencing of paired SCLC tumor samples procured at diagnosis and relapse from 12 patients, and unpaired relapse samples from 18 additional patients. Multiple somatic copy number alterations, including...

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PMID: 30224629
DOI: 10.1038/s41467-018-06162-9

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