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Article

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.

Carcinogenesis - 1 Jun 2015

Iwakawa Reika, Kohno Takashi, Totoki Yasushi, Shibata Tatsuhiro, Tsuchihara Katsuya, Mimaki Sachiyo, Tsuta Koji, Narita Yoshitaka, Nishikawa Ryo, Noguchi Masayuki, Harris Curtis C, Robles Ana I, Yamaguchi Rui, Imoto Seiya, Miyano Satoru, Totsuka Hirohiko, Yoshida Teruhiko, Yokota Jun

Abstract excerpt

Small cell lung cancer (SCLC) is the most aggressive type of lung cancer. Only 15% of SCLC patients survive beyond 2 years after diagnosis. Therefore, for the improvement of patients' outcome in this disease, it is necessary to identify genetic alterations applicable as therapeutic targets in SCL...

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Source

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Identifiers

PMID: 25863124
DOI: 10.1093/carcin/bgv026
PMCID: PMC4462675

Genes

SPTA1
PTEN
ANK2
ASPM
ASTN1
CSMD2
FBN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25863124-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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