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Article

Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models.

BMC medicine - 22 Jan 2026

Wang Xueting, He Jun, Cabrera-Mendoza Brenda, Qiu Dan, Mao Zhongzheng, Gu Wen, Liu Youwen, Kim Jihoon, Polimanti Renato

Abstract excerpt

BACKGROUND: Patients with asthma have an increased risk of developing depression, affecting their quality of life. To date, the processes contributing to this comorbidity remain unclear. METHODS: We integrated two large genome-wide association studies (88,486 patients with asthma and 447,859 controls; 412,024 patients with depression and 1,587,577 controls) with cross-sectional and longitudinal information...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41572266
DOI: 10.1186/s12916-026-04646-w
PMCID: PMC12910895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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