Article
Digital PCR After MALDI-Mass Spectrometry Imaging to Combine Proteomic Mapping and Identification of Activating Mutations in Pulmonary Adenocarcinoma.
Proteomics. Clinical applications - 1 Jan 2019
Kazdal Daniel, Longuespée Rémi, Dietz Steffen, Casadonte Rita, Schwamborn Kristina, Volckmar Anna-Lena, Kriegsmann Jörg, Kriegsmann Katharina, Fresnais Margaux, Stenzinger Albrecht, Sültmann Holger, Warth Arne, Kriegsmann Mark
Abstract excerpt
PURPOSE: Matrix assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-MSI) is a powerful tool to analyze the spatial distribution of peptides in tissues. Digital PCR (dPCR) is a method to reliably detect genetic mutations. Biopsy material is often limited due to minimally invasive techniques, but information on diagnosis, prognosis, and prediction is required for subsequent clinical...
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