Article

Integrating UHPLC-MS and MALDI-MSI for Spatial Nucleoside Profiling in FFPE Breast Cancer: A Multimodal Molecular Pathology Framework

2026-01-30

Abstract excerpt

<h4>ABSTRACT</h4> Formalin-fixed, paraffin-embedded (FFPE) tissues constitute the primary material for diagnostic pathology and retrospective clinical research, yet their use in metabolomics remains limited due to molecular cross-linking and analyte degradation. Here, we establish a cost-efficient molecular pathology workflow that integrates ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS...

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Literature Corpus work: 5bec7166-895c-5a62-bc2a-fe944e45a1ed
DOI: 10.64898/2026.01.28.701949

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