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Article

Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations.

PLoS genetics - 1 Sept 2018

Hart Matthew R, Anderson Donovan J, Porter Christopher C, Neff Tobias, Levin Michael, Horwitz Marshall S

Abstract excerpt

PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and heterozygous germline loss-of-function PAX5 mutations cause autosomal dominant predisposition to ALL. At least in...

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Identifiers

PMID: 30216339
DOI: 10.1371/journal.pgen.1007642
PMCID: PMC6157899

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