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Article

Gene-Hormone Therapy Interaction and Fracture Risk in Postmenopausal Women.

The Journal of clinical endocrinology and metabolism - 1 Jun 2017

Wang Youjin, Wactawski-Wende Jean, Sucheston-Campbell Lara E, Preus Leah, Hovey Kathleen M, Nie Jing, Jackson Rebecca D, Handelman Samuel K, Nassir Rami, Crandall Carolyn J, Ochs-Balcom Heather M

Abstract excerpt

Context: Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored. Objective: The objective was to test an interaction between genetic susceptibility and HT on fracture risk. Design: We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28324062
DOI: 10.1210/jc.2016-2936
PMCID: PMC5470770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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