Article
Genomic profiles of primary and metastatic esophageal adenocarcinoma identified via digital sorting of pure cell populations: results from a case report.
BMC cancer - 12 Sept 2018
Isidori Federica, Malvi Deborah, Fittipaldi Silvia, Forcato Claudio, Bozzarelli Isotta, Sala Claudia, Raulli Giovanni, D'Errico Antonia, Fiorentino Michelangelo, Seri Marco, Krishnadath Kausilia K, Bonora Elena, Mattioli Sandro
Abstract excerpt
BACKGROUND: We report on a female patient who underwent primary radical resection for a stage 2B Her-2-positive Barrett's-type esophageal adenocarcinoma (EAC). Despite Her-2 targeted therapy, her disease recurred and required repeated metastectomies. CASE PRESENTATION: Digital cell sorting and targeted sequencing of cancer sub-clones from EAC and metastases revealed a completely mutated TP53, whereas the sorted...
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