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Article

HER2 expression identifies dynamic functional states within circulating breast cancer cells.

Nature - 1 Sept 2016

Jordan Nicole Vincent, Bardia Aditya, Wittner Ben S, Benes Cyril, Ligorio Matteo, Zheng Yu, Yu Min, Sundaresan Tilak K, Licausi Joseph A, Desai Rushil, O'Keefe Ryan M, Ebright Richard Y, Boukhali Myriam, Sil Srinjoy, Onozato Maristela L, Iafrate Anthony J, Kapur Ravi, Sgroi Dennis, Ting David T, Toner Mehmet, Ramaswamy Sridhar, Haas Wilhelm, Maheswaran Shyamala, Haber Daniel A

Abstract excerpt

Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targeted therapy, the clinical significance of acquired HER2 heterogeneity during the evolution of...

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Source

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Identifiers

PMID: 27556950
DOI: 10.1038/nature19328
PMCID: PMC5161614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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