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Article

The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

PLoS pathogens - 1 May 2014

Solans Luis, Gonzalo-Asensio Jesús, Sala Claudia, Benjak Andrej, Uplekar Swapna, Rougemont Jacques, Guilhot Christophe, Malaga Wladimir, Martín Carlos, Cole Stewart T

Abstract excerpt

The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specific cell wall components and attenuation both ex vivo and in vivo. Using antibodies against the native protein in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24874799
DOI: 10.1371/journal.ppat.1004183
PMCID: PMC4038636

Genes

TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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