Article
Pharmacogenetic variants influence vitamin K anticoagulant dosing in patients with mechanical prosthetic heart valves.
Pharmacogenomics - 1 Jun 2022
Koshy Linda, Vb Raghu, M Madhuma, Ben Midhuna P, Kishor Pritam, Sudhakaran P R, Abdullakutty Jabir, Venugopal K, Zachariah Geevar, Mohanan P P, Harikrishnan S, G Sanjay
Abstract excerpt
Background: Vitamin K antagonists (VKAs) are class I oral anticoagulants that are widely prescribed following surgical heart valve implantation. The objective of this study was to quantify the relative effects of VKORC1, CYP2C9 and CYP4F2 genotypes in predicting VKA dosing. Materials & methods: A total of 506 South Indian patients with mechanical prosthetic heart valves who were prescribed oral VKAs, such as...
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