Article
Functional elucidation of TfuA in peptide backbone thioamidation.
Nature chemical biology - 1 May 2021
Liu Andi, Si Yuanyuan, Dong Shi-Hui, Mahanta Nilkamal, Penkala Haley N, Nair Satish K, Mitchell Douglas A
Abstract excerpt
YcaO enzymes catalyze several post-translational modifications on peptide substrates, including thioamidation, which substitutes an amide oxygen with sulfur. Most predicted thioamide-forming YcaO enzymes are encoded adjacent to TfuA, which when present, is required for thioamidation. While activation of the peptide amide backbone is well established for YcaO enzymes, the function of TfuA has remained enigmatic....
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