Article
Shaping robust system through evolution.
Chaos (Woodbury, N.Y.) - 1 Jun 2008
Kaneko Kunihiko
Abstract excerpt
Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype. Here we study how this dynamical system is robust to noise during development and to genetic change by mutation. We adopt a simplified transcription regulation...
Topics
- Animals
- Biological Evolution
- Biophysics
- Epigenesis, Genetic
- Evolution, Molecular
- Gene Expression Regulation
- Genetics, Population
- Humans
- Models, Genetic
- Models, Statistical
- Mutation
- Phenotype
- Systems Theory
- Temperature
- Transcription, Genetic
