Genes under weaker stabilizing selection increase network evolvability and rapid regulatory adaptation to an environmental shift.

Abstract excerpt

Regulatory networks play a central role in the modulation of gene expression, the control of cellular differentiation, and the emergence of complex phenotypes. Regulatory networks could constrain or facilitate evolutionary adaptation in gene expression levels. Here, we model the adaptation of regulatory networks and gene expression levels to a shift in the environment that alters the optimal expression level of a...

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• Adaptation, Physiological
• Environment
• Gene Regulatory Networks
• Models, Genetic
• Phenotype