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Article

A G-Quadruplex Structure in the Promoter Region of CLIC4 Functions as a Regulatory Element for Gene Expression.

International journal of molecular sciences - 10 Sept 2018

Huang Mu-Ching, Chu I-Te, Wang Zi-Fu, Lin Steven, Chang Ta-Chau, Chen Chin-Tin

Abstract excerpt

The differential transcriptional expression of CLIC4 between tumor cells and the surrounding stroma during cancer progression has been suggested to have a tumor-promoting effect. However, little is known about the transcriptional regulation of CLIC4. To better understand how this gene is regulated, the promoter region of CLIC4 was analyzed. We found that a high GC content near the transcriptional start site (TSS)...

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Identifiers

PMID: 30201851
DOI: 10.3390/ijms19092678
PMCID: PMC6165315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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