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Article

Identification and characterization of a new G-quadruplex forming region within the kRAS promoter as a transcriptional regulator.

Biochimica et biophysica acta - 1 Feb 2016

Morgan Rhianna K, Batra Harshul, Gaerig Vanessa C, Hockings Jennifer, Brooks Tracy A

Abstract excerpt

kRAS is one of the most prevalent oncogenic aberrations. It is either upregulated or mutationally activated in a multitude of cancers, including pancreatic, lung, and colon cancers. While a significant effort has been made to develop drugs that target kRAS, their clinical activity has been disappointing due to a variety of mechanistic hurdles. The presented works describe a novel mechanism and molecular target to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26597160
DOI: 10.1016/j.bbagrm.2015.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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