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Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 <sup>+</sup> T cells underlies distinct functional potential

2025-08-11

Abstract excerpt

Persistent antigen stimulation promotes differentiation of exhausted CD8 + T (T EX ) cells. T EX cells are distinct from circulating memory T (T CIRCM ) cells but share many features with tissue-resident memory (T RM ) cells established following infection resolution. CD8 + T cells co-expressing residency- and exhaustion-associated molecules in chronic diseases often correlate with clinical outcomes. However...

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Literature Corpus work
5d597b3d-13ef-56af-9a5f-d011f02e4476
DOI
10.1101/2025.08.08.669213
Open publication

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Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 <sup>+</sup> T cells underlies distinct functional potentialDOI 10.1101/2025.08.08.669213
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