Article
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Blood - 8 Nov 2018
Sud Amit, Thomsen Hauke, Orlando Giulia, Försti Asta, Law Philip J, Broderick Peter, Cooke Rosie, Hariri Fadi, Pastinen Tomi, Easton Douglas F, Pharoah Paul D P, Dunning Alison M, Peto Julian, Canzian Federico, Eeles Rosalind, Kote-Jarai ZSofia, Muir Kenneth, Pashayan Nora, Campa Daniele, Hoffmann Per, Nöthen Markus M, Jöckel Karl-Heinz, von Strandmann Elke Pogge, Swerdlow Anthony J, Engert Andreas, Orr Nick, Hemminki Kari, Houlston Richard S
Abstract excerpt
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 × 10-10), 6q23.3 (rs1002658; P = 2.97 × 10-8), 11q23.1 (rs7111520; P = 1.44 × 10-11), 16p11.2 (rs6565176; P = 4.00 × 10-8), and 20q13.12 (; P =...