Article
MicroRNA-124-3p inhibits collagen synthesis in atherosclerotic plaques by targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) in vascular smooth muscle cells.
Atherosclerosis - 1 Oct 2018
Chen Wei'jia, Yu Fangpu, Di Mingxue, Li Mengmeng, Chen Yifei, Zhang Yu, Liu Xiaolin, Huang Xiaozhen, Zhang Mei
Abstract excerpt
BACKGROUND AND AIMS: Collagen synthesis in vascular smooth muscle cells (VSMCs) is very important in atherosclerosis, as it affects plaque stability. In this study, we aim to assess whether miR-124-3p is involved in the collagen synthesis process in VSMCs and the role it might play in atherosclerotic development. METHODS: We modulated the miR-124-3p expression in the aortic root plaques of high-fat-diet fed...
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