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Article

Comparative Analysis of 3D Bladder Tumor Spheroids Obtained by Forced Floating and Hanging Drop Methods for Drug Screening

22 Aug 2017

Abstract excerpt

<bold>Introduction:</bold> Cell-based assays using three-dimensional (3D) cell cultures may reflect the antitumor activity of compounds more accurately, since these models reproduce the tumor microenvironment better. <bold>Methods:</bold> Here, we report a comparative analysis of cell behavior in the two most widely employed methods for 3D spheroid culture, forced floating (Ultra-low Attachment, ULA, plates), and...

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PMID: 28878686
DOI: 10.3389/fphys.2017.00605

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