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Article

Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres.

Journal of cellular physiology - 1 Sept 2017

Yakisich Juan Sebastian, Azad Neelam, Kaushik Vivek, Iyer Anand Krishnan V

Abstract excerpt

In cancer cells, the reversible nature of the stemness status in terms of chemoresistance has been poorly characterized. In this study, we have simulated one cycle of environmental conditions to study such reversibility by first generating floating tumorspheres (FTs) from lung and breast cancer cells by culturing them in serum-free media without the addition of any external mitogenic stimulation, and subsequently...

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Identifiers

PMID: 27925198
DOI: 10.1002/jcp.25725
PMCID: PMC5444977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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