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Article

Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin.

Molecular and cellular biology - 1 May 2010

Hoi Charlene S L, Lee Song Eun, Lu Shu-Yang, McDermitt David J, Osorio Karen M, Piskun Caroline M, Peters Rachel M, Paus Ralf, Tumbar Tudorita

Abstract excerpt

Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in morphogenesis impairs normal adult hair homeostasis (cycle) and blocks adult hair follicle stem cells (HFSCs) in quiescence. Here, we show that these effects are overcome later in adulthood. By deleting Runx1 after the end of...

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Identifiers

PMID: 20308320
DOI: 10.1128/MCB.01308-09
PMCID: PMC2863705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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